super advanced USP grade Auxiliary agent croscarmellose sodium raw material CAS NO.74811-65-7

Min.Order: 25 Kilogram
Payment Terms: L/C,D/A,D/P,T/T,

Product Details

Keywords

croscarmellose sodium raw material
USP gradec CC-NA
Auxiliary agent CC-NA

Quick Details

ProName: super advanced USP grade Auxiliary age...
CasNo: 74811-65-7
Molecular Formula: (C6H10O6)n(C2H2O2Na)x
Application: tablet super disintegrant
DeliveryTime: 7-15days
PackAge: net weight:25kgs/fabric drum
Port: shanghai
ProductionCapacity: 100 Kilogram/Month
Purity: 99%
LimitNum: 25 Kilogram
APPLICATION: tablet super disintegrant
grade: pharmaceutical grade

Superiority

super advanced USP grade Auxiliary agent croscarmellose sodium raw material

FOBprice:$15-$25/kg

MOQ:25kgs/drum

USP BP.EP STANDARD

Details

Product Name

croscarmellose sodium; Crosscarmelosesodium

Synonym

PRIMELLOSE; Croscarmellose natrium; Cross-linked sodium carboxymethylcellulose; Vivasol

CAS No.:

74811-65-7

MF:

(C6H10O6)n(C2H2O2Na)x

MW：

N/A

Hs code

3912 3100 00

Chemial Formula

N/A

PICTURE:

Physical properties:

White or off white; Free flowing fibrous powder, very hygroscopic.

Practically insoluble in anhydrous Acetone, Ethanol, Ether and Toluene

Disintegration performance

Cross-linking of carboxymethyl cellulose fibers reduces water solubility, and the resulting material can take up many times its own weight of water and swell power fully without losing its fibrous integrity. The combination of rapid water penetration into tablets through the hydrophilic, fibrous particles and the subsequent development of a strong disintegration force make croscarmellose sodium a very effective superdisintegrant. It is one of the most effective superdisintegrant available because of the strong swelling force which it develops. The effectiveness may be attributed to a combination of its particle size and optimal degree of substitution.

Parameters	Specification
Description	Free flowing powder, Very hygroscopic powder
Color	White or off white
Solubility	Practically insoluble in Acetone, Ethanol, Ether and Toluene
Identification (A,B,C) , (1,2,3)	Have to correspond as USP/NF,JP,Ph.Eur.,BP
Degree of Substitution	0.60 to 0.85 as USP/NF,JP,Ph.Eur.,BP
Loss on Drying	NMT 10.0% as USP/NF,JP,Ph.Eur.,BP
pH	5.0-7.0 as USP/NF,JP,Ph.Eur.,BP
Content of water Soluble Substance	NMT 10.0 % as USP/NF,JP,Ph.Eur.,BP
Residue on Ignition / Sulphated Ash	14.0% to 28.0% as USP/NF,JP,Ph.Eur.,BP
Settling Volume	10 to 30 ml as USP/NF,JP,Ph.Eur.,BP
Sodium Chloride & Sodium Glycollate	NMT 0.5 % as USP/NF,,Ph.Eur.,BP
Heavy Metals	NMT 10 PPM as USP/NF, Ph.Eur.,BP
Iron	NMT 10 PPM as USP/NF, Ph.Eur.,BP

Application:

Rapid disintegrator in pharmaceutical formulations for tablets, capsules and granules.

effective for combination with both insoluble filler-binders, such as MCC and DCP and slightly soluble to soluble filler-binders such as mannitol and lactose at concentrations of 2-6%

It can also be preferred for non-starch base formulation product.

effective when used as intra-granular or extra-granular super disintegrant or when divided between these locations.

Tablet dissolution can be greatly increased by the use of a super disintegrate.

Efficient for low use of levels.

Insensate hardness of tablet.

Finer dissolution stability for long term.

Used in solid dosages vitamin and nutrition.

Storage and packing

Pack Size: 25 KGS/drum

Packing is done as required by the end user, and all above said options contains inside LDPE liner.